ea0015oc4 | Young Endocrinologist prize session | SFEBES2008
Elsby Laura
, Donn Rachelle
, Alourfi Zaynab
, Beaulieu Elaine
, Ray David
MIF is a potent pro-inflammatory mediator that opposes the anti-inflammatory actions of glucocorticoids (Gc) and is involved in the pathogenesis of multiple diseases. The MIF promoter is inhibited by Gc in lymphocytes (CEMC7A) but not in epithelial cells (A549), despite expression of functional glucocorticoid receptors (GR) in both. Deletion studies localized the cis element responsible for Gc inhibition to between MIF −71 and +85. This sequence contained no GR binding s...